{"title":"Antipsychotika: Tabelle II","body":"Antipsychotika<\/STRONG>\n

Tab. 2:<\/STRONG> Rezeptoraffinitäten einiger Antipsychotika<\/I><\/P>\n

<\/P>\n
\n\n\n\n\n\n\n\n\n\n\n
\nAntipsychotikum\n<\/TD>\n\nAffinität für Rezeptoren\n<\/TD>\n<\/TR>\n
\nDopamin-Rezeptor\n<\/TD>\n\nSerotonin-Rezeptor\n<\/TD>\n\nadrenerger Rezeptor \n<\/TD>\n\nHistamin-
<\/BR>Rezeptor\n<\/TD>\n<\/TR>\n
\nD1<\/SUB>\n<\/TD>\n\nD2<\/SUB>\n<\/TD>\n\nD4<\/SUB>\n<\/TD>\n\n5HT2A<\/SUB>\n<\/TD>\n\n5HT2C<\/SUB>\n<\/TD>\n\nα1<\/SUB>\n<\/TD>\n\nα2<\/SUB>\n<\/TD>\n<\/TR>\n
\nClozapin1<\/SUP>\n<\/TD>\n\n85\n<\/TD>\n\n126\n<\/TD>\n\n9\n<\/TD>\n\n12\n<\/TD>\n\n8\n<\/TD>\n\n7\n<\/TD>\n\n8\n<\/TD>\n\n6\n<\/TD>\n<\/TR>\n
\nHaloperidol1<\/SUP>\n<\/TD>\n\n25\n<\/TD>\n\n1\n<\/TD>\n\n5\n<\/TD>\n\n78\n<\/TD>\n\n>1000\n<\/TD>\n\n46\n<\/TD>\n\n360\n<\/TD>\n\n>1000\n<\/TD>\n<\/TR>\n
\nOlanzapin1<\/SUP>\n<\/TD>\n\n31\n<\/TD>\n\n112\n<\/TD>\n\n27\n<\/TD>\n\n4\n<\/TD>\n\n11\n<\/TD>\n\n19\n<\/TD>\n\n228\n<\/TD>\n\n7\n<\/TD>\n<\/TR>\n
\nQuetiapin1<\/SUP>\n<\/TD>\n\n455\n<\/TD>\n\n160\n<\/TD>\n\n?\n<\/TD>\n\n220\n<\/TD>\n\n615\n<\/TD>\n\n7\n<\/TD>\n\n87\n<\/TD>\n\n11\n<\/TD>\n<\/TR>\n
\nRemoxiprid1<\/SUP>\n<\/TD>\n\n>1000\n<\/TD>\n\n274\n<\/TD>\n\n>1000\n<\/TD>\n\n>1000\n<\/TD>\n\n>1000\n<\/TD>\n\n>1000\n<\/TD>\n\n>1000\n<\/TD>\n\n>1000\n<\/TD>\n<\/TR>\n
\nRisperidon1<\/SUP>\n<\/TD>\n\n75\n<\/TD>\n\n3\n<\/TD>\n\n7\n<\/TD>\n\n0,6\n<\/TD>\n\n26\n<\/TD>\n\n2\n<\/TD>\n\n3\n<\/TD>\n\n155\n<\/TD>\n<\/TR>\n
\nSertindol2<\/SUP>\n<\/TD>\n\n26\n<\/TD>\n\n41\n<\/TD>\n\n?\n<\/TD>\n\n0,39\n<\/TD>\n\n?\n<\/TD>\n\n3,4\n<\/TD>\n\n350\n<\/TD>\n\n600\n<\/TD>\n<\/TR>\n
\nZiprasidon1<\/SUP>\n<\/TD>\n\n68\n<\/TD>\n\n8\n<\/TD>\n\n7,4\n<\/TD>\n\n9\n<\/TD>\n\n8\n<\/TD>\n\n7,9\n<\/TD>\n\n?\n<\/TD>\n\n7,3\n<\/TD>\n<\/TR>\n\n<\/TABLE><\/TD><\/TR><\/TABLE>\n

1<\/SUP> Affinität dargestellt durch Angabe der Inhibitionskonstante Ki<\/SUB>=[Rezeptor]·[Substanz]\/[Komplex] (nmol\/l)
<\/BR>2<\/SUP> Affinität dargestellt durch Angabe der Substanzkonzentration, die den Rezeptor zu 50 % blockiert.<\/P>"}